1/16/2023 0 Comments Silk protein scaffold![]() ![]() The investigators hypothesize that the novel silk protein microparticle-based filler will have a favorable safety profile for use as an injectable material in the human larynx and it will produce durable clinical benefit lasting up to 12 months. Outcome measures evaluated pre- and post-injection and over follow-up visits will include various patient reported quality of life indices, objective clinical assessments of voice, laryngeal videostroboscopy examinations, and acoustic/aerodynamic testing. Patients with unilateral vocal fold paralysis identified at the study sites will be offered participation in this study to receive injection augmentation of the paralyzed vocal fold with the filler material under investigation. Given the potential advantages of such a material, Brown et al engineered and studied a novel silk protein microparticle-based filler material suitable for injection augmentation. Surgical scaffolds derived from silk have been used for reconstructive surgery, due to its ability to allow cellular infiltration and encourage tissue regeneration/remodeling. Silk is derived from the Bombyx mori silk worm and has a long history as a surgical biomaterial. However, all of the current injection choices have individual limitations such as temporary effect, unpredictability due to variable resorption by the body, unfavorable mechanical properties, and challenging handling attributes. Various materials are used for injection augmentation including autologous fat, hyaluronic acid, collagen, carboxymethylcellulose, and calcium hydroxyapatite. Injection augmentation has many advantages including its minimally invasive nature, overall safety and low risk/complication rate, immediate clinical effect, and ability to perform it at the bedside or in-office. One manner in which this is done is via injection of a filler or bulking agent into the vocal fold in order to augment it. The presence of vocal fold paralysis with glottal insufficiency can lead to decreased quality-of-life, as well as increase risks of complications such as aspiration pneumonia.Ĭurrent treatments for vocal fold paralysis are based around techniques to medialize the paralyzed vocal fold. It often results in glottal insufficiency, which is the inability of the true vocal folds to meet and achieve complete closure during normal physiologic functions such as speech, swallowing, and coughing. Vocal fold paralysis is a clinical condition that arises commonly as a complication of surgery, endotracheal intubation, malignancy, or idiopathic etiologies. Why Should I Register and Submit Results?.Further development of silk-based scaffolds for bone tissue engineering, taking them up to and beyond the stage of human trials, is hoped to be achieved in the near future through a cross-disciplinary coalition of tissue engineers, material scientists and manufacturing engineers. A growing trend is observed toward the use of mineralized and nanofibrous scaffolds along with the development of technology that allows to control scaffold architecture, its biodegradability and the sustained releasing property of scaffolds. Several successful works, both in vitro and in vivo, have been reported using silk-based scaffolds to regenerate bone tissues or other parts of the skeletal system such as cartilage and ligament. Silk has also been blended with a variety of polymers and minerals to enhance its advantageous properties or introduce new ones. Silk surfaces offer active sites that aid the mineralization and/or bonding of bioactive molecules that facilitate bone regeneration. This makes silk-based scaffolds suitable for treating a variety of bone reconstruction and regeneration objectives. ![]() As silk is an easy-to-process biopolymer this allows silk-based biomaterials to be molded into diverse forms and architectures, which further affects the degradability. The current work presents an overview of this literature from materials and fabrication perspective. A vast body of literature is available on the use of silk in bone tissue engineering. This increased elderly population pushes the need for artificial bone implants that specifically employ biocompatible materials. This makes it an ideal cellular scaffold, distinguished from most other structural proteins used in tissue support and regeneration, such as collagen. Moreover, as the world population continues to grow, the percentage of the elderly population continues to grow, which results in an increased number of bone degenerative diseases. The frequency of accidental bone damage and disorder is increasing worldwide. Bone tissue plays multiple roles in our day-to-day functionality. Researchers have synthesised a silk-protein-based scaffold that can help regenerate liver cells 1.These artificially grown liver cells are capable of mimicking the functions and growth of normal. ![]()
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